CD36 expression and its relationship with obesity in blood cells from people with and without Prader-Willi syndrome.

Webb T, Whittington J, Holland AJ, Soni S, Boer H, Clarke D, Horsthemke B.

Section of Medical and Molecular Genetics, University of Birmingham, Birmingham, UK.

Summary by Jamie H. Bassel, D.C., P.C.

 It has been well established that PWS has been attributed to a partial deletion of the gene 15q11q13.  However, very little has been studied about the cause of the deletion.  This recent study demonstrates that there has been an irregularity of CD36 expression in individuals displaying maternal uniparental disomy 15.  CD36 is expressed on many cell types, including some blood cells. Its critical role in fatty acid metabolism has recently been proven^.  Using specific techniques, the research has demonstrated a reduction in CD36 expression on blood cells appears to be consistent with maternal UPD.  In non-PWS individuals body mass index (BMI) and CD36 expression are inversely proportioned.  However, CD36 expression in PWS individuals this correlation does not exist.  CD36 expression and its circulating blood levels are directly linked to controlling a balance between fat and blood sugar metabolism.    This study further describes the possible explanation of the voracious appetites in PWS patients.

Abstract - click here

edited: 08/19/2008