Two years of growth hormone therapy in young children with Prader-Willi Syndrome: Physical and Neurodevelopmental benefits.

Myers SE, Whitman BY, Carrel AL, Moerchen V, Bekx MT, Allen DB

Am J Genet A 2006 Nov 13 

Growth hormone Therapy (GH) in children with PWS helps develop but does not return to normal, body composition, muscle might and dexterity.  The purpose of this study was to evaluate the effects of GH on various body measurements (percent body fat, lean body mass, total bone density, cognitive and language evaluations, mobility assessments.  The study revealed that those treated with GH before their first birthday spoke their first words at approximately 14 months and walked without assistance at roughly 2 years.  Based upon this study, a pediatric endocrinology evaluation followed by implementation of GH therapy is advised in individuals with PWS as early as possible. 

Abstract - click here

edited: 08/19/2008