Research Summaries

Please note: While each of the following projects may be of interest to PWSA members, not all are sponsored by PWSA. For information on funding of a given project, please contact the applicable researcher. For information on PWSA's funding of research projects, click here.

Summaries by Dr. Mayim Chaya Bialik serves on the PWSA (USA) Research Advisory Board.

• Selective Deletion of Bdnf in the Ventromedial and Dorsomedial Hypothalamus of Adult Mice Results in Hyperphagic Behavior and Obesity

Summaries by Jamie H. Bassel, D.C., P.C.

• Exendin-4 potently decreases ghrelin levels in fasting rats. - 2006 Dec.
  Perez-Tilve D, Gonzalez-Matias L, Alvarez-Crespo M, Leiras R, Tovar S, Dieguez C, Mallo F.
• Enhanced activation of reward-mediating prefrontal regions in response to food stimuli in prader-willi syndrome. - 2006 Dec.
  Miller JL, James GA, Goldstone AP, Couch JA, He G, Driscoll DJ, Liu Y
   
• Two years of growth hormone therapy in young children with Prader-Willi Syndrome: Physical and Neurodevelopmental benefits.
  Myers SE, Whitman BY, Carrel AL, Moerchen V, Bekx MT, Allen DB
   
• Intracranial abnormalities detected by three-dimensional magnetic resonance imaging in Prader-Willi syndrome - 2006 Nov.
  Miller JL, Couch JA, Schmalfuss I, He G, Liu Y, Driscoll DJ.
   
• C-reactive protein levels in subjects with Prader-Willi syndrome and obesity. - 2006 Apr.
  Butler MG, Bittel DC, Kibiryeva N, Garg U.
   
• Obesity and the pulmonologist. - 2006 Feb.
  Deane S, Thomson A.
  Department of Paediatrics, John Radcliffe Hospital, Oxford, UK.
   
• Repetitive and ritualistic behaviour in children with Prader-Willi syndrome and children with autism. - 2006 Feb.
  Greaves N, Prince E, Evans DW, Charman T.
  Islington Primary Care NHS Trust, London, UK. 
   
• CD36 expression and its relationship with obesity in blood cells from people with and without Prader-Willi syndrome. - 2006 Jan
  Webb T, Whittington J, Holland AJ, Soni S, Boer H, Clarke D, Horsthemke B.
  Section of Medical and Molecular Genetics, University of Birmingham, Birmingham, UK.
   
• Suppression of acylated ghrelin during oral glucose tolerance test is correlated with whole body insulin sensitivity in children with Prader-Willi syndrome. - 2006 Feb.
  Paik KH, Choe YH, Park WH, Oh YJ, Kim AH, Chu SH, Kim SW, Kwon EK, Han SJ, Shon WY, Jin DK
  Department of Pediatrics (K.H.P, Y.H.C., E.K.K., W.Y.S., D.-K.J.), Department of Orthopedic Sports Medicine (W.H.P), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; Clinical Research Center (Y.J.O., A.H.K., S.H.C, S.W.K., S.J.H), Samsung Biomedical Research Institute, Seoul, Korea.
   
• Exclusion of the C/D box snoRNA gene cluster HBII-52 from a major role in Prader-Willi syndrome - 2005 Feb.
  Maren Runte, Raymonda Varon, Denise Horn, Bernhard Horsthemeke, Karen Buiting
  Institut fur Humangenetik, Universitatsklinikum Essen, Hufelandstrasse 55, 45122, Essen, Germany.
   
• Hypothalamic and Gonadal Components of Hypogonadism in Boys with Prader-Labhart-Willi Syndrome - 2006 - Mar.
  Urs Eiholzer, Dagmar L’Allemand, Valentin Rousson, Michael Schlumpf, Theo Gasser, Jurg Girard, Annette, Gruters, and Manuela Simoni
  Institute Growth Puberty Adolescence, Moehrlistrasse 69, CH-8006 Zurich, Switzerland. mail@childgrowth.org

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 edited: 08/19/2008