New Clue for Understanding the
Hunger of Prader-Willi Syndrome: Research Volunteers are
Needed for Further Studies
July 2010 issue of The Journal of Clinical Endocrinology
& Metabolism, Dr. Joan C. Han, a pediatric
endocrinologist at the National Institutes of Health (NIH),
and her colleagues reported the results of a small pilot
study of 13 patients with PWS. They observed that
patients with PWS appear to have lower blood
concentrations of brain-derived neurotrophic factor (BDNF).
BDNF is a protein that is believed to play an important
role in controlling appetite and may provide some
answers to understanding the insatiable hunger of PWS
and other conditions associated with hyperphagia. Dr.
Han and her colleagues recently received a grant from
the PWSA (USA) to conduct further studies on BDNF, and
they are seeking patients with PWS (ages 0-18 years old)
for this research. Participation involves providing
medical information and a blood sample. For more
information, please contact Dr. Han at (301) 435-7820 or
PWSA (USA) participation in this project does not imply
endorsement, approval, or recommendation by PWSA (USA)
for any products or services.